Grapefruit seed extract is a highly concentrated G.I. balancing extract promoting healthy microflora and gut ecology. A preliminary clinical trial reported that grapefruit seed extract supplements helped support healthy G.I. function and comfort. An in vitro study indicated that grapefruit seed extract promoted healthy microbial balance. Other studies support these findings, citing that grapefruit seed extract promotes a healthy environment when exposed to a wide range of bacterial biotypes.